Ketamine Assisted Psychotherapy for Depression, Anxiety, & PTSD Serving Sacramento, CA


What ketamine?

Ketamine is a legal, safe, and effective anesthetic medicine approved in 2019 for off-label use by the FDA to treat depression. Preliminary evidence shows it is also effective for PTSD, social anxiety, and obsessive-compulsive disorder. Ketamine has rapidly-acting antidepressant and mood-enhancing effects, which can begin to take effect within one to two hours after treatment and last up to two weeks. Ketamine has also been shown to enhance overall neuroplasticity for lasting symptom improvement.

“Science is magic that works.” ~ Kurt Vonnegut

The science:

Ketamine was developed by Calvin S. Stevens, a chemistry professor, in 1962. Ketamine acts as a dissociative anesthetic, procedural sedative, painkiller, and novel antidepressant. Its safety, short duration, and unique mode of action have made Ketamine an essential medication in emergency medicine worldwide. It works by blocking the brain’s N-methyl-D-aspartate (NMDA) receptors, a type of glutamate receptor, and stimulating AMPA receptors, which are believed to help form new synaptic connections and boost neural circuits that regulate stress and mood.

The study and use of Ketamine for chronic pain, drug addiction, and psychiatric disorders have grown considerably in the last few decades. The most significant finding is a discovery of Ketamine’s rapid-acting antidepressant effects (Kohtala, 2001), often within hours, with 50-80% efficacy. This is welcome news for the mental health community, which has not benefited from rapid medical advancements like other healthcare areas. For instance, while antidepressants are helpful for many, they take weeks to months for effects and have a 33% efficacy rate. In other words, antidepressants end depression for only a third of the severely depressed patients who take them. As such, in 2019, the FDA authorized Ketamine’s off-label use for treatment-resistant depression and anxiety. It is used regularly in emergency rooms to abate suicidality quickly. Off-label means it is used for something other than initially intended. Treatment-resistant means medications and psychotherapy have failed to remit a person’s depression.

What are ketamine’s benefits?

Our clients have experienced many benefits, including:

A relaxing time-out from ordinary thinking and reality

Decrease in negative or obsessive thoughts

Shifts in self-perspective, relationships, and worldview

Increase in self-compassion and self-identity

Increased creativity and cognitive flexibility

A broader outlook on challenging situations and problems

Reduction of fear and disruption of painful memories

Improved neuroplasticity and dendritic growth

Reversal of cellular damage caused by stress

Intrinsic antidepressant response

Improved ability to experience happiness and pleasure

Changes in rejection sensitivity

Changes in avoidance behaviors (e.g., not speaking up to avoid conflict, going out of your way to avoid seeing someone, not looking at mail to avoid seeing bills)

A spiritual or mystical experience—which can vary for different individuals

Any activity, behavior, or cognitive practice a person engages in after ketamine treatment, referred to as the “neuroplastic window,” will be naturally enhanced. During this time, neurons and dendrites experience more rapid and robust growth as the brain is bathed in brain-derived neurotropic factor (BDNF). The neuroplastic window can last 7 to 10 days.

How is Ketamine administered?

Ketamine can be administered via IV infusion, intramuscular injection, nasal spray, or sublingual lozenges. Sublingual lozenges are used in KAPspotting.

A medical provider must administer IV infusion and intramuscular injection. A medical doctor must prescribe nasal spray and sublingual lozenges. We use lozenges in KAPspotting because they are fast acting, where effects are felt within minutes. The effects last 45-60 minutes.

Our partnership with a local infusion clinic is headed by a board-certified anesthesiologist with many years of ketamine experience. It is available there if he deems you are a good candidate for IV infusion.

How does Ketamine treatment feel?

Most people find the effects of ketamine to be pleasant. Effects include shifts in perception that often feel expansive, described as feeling greater openness to ideas and information. Patients often report a sense of unity with all things and a general perception of not being separate but interconnected with themselves and their surroundings.

At lower doses, clients remain conscious, feel more open, and are less fearful of discussing painful memories, thoughts, and feelings, leading to a quicker resolution. Moderate-to-high doses involve dissociation, out-of-body experiences, and a greater sense of connection to others and may include mystical or spiritual experiences. While it may feel hard to articulate what happened during the experience, patients feel like the insights gained are clear. Studies have shown that mood and neurological growth benefits continue weeks after the Ketamine experience.

The effects last 45-60 minutes.

IV infusion, intramuscular injection, nasal spray, or sublingual lozenges.

Pleasant Feeling

Sources:, Dore J, Turnipseed B, Dwyer S, Turnipseed A, Andries J, Ascani G, Monnette C, Huidekoper A, Strauss N, Wolfson P. Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data, and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy. J Psychoactive Drugs. 2019 Apr-Jun;51(2):189-198. Doi: 10.1080/02791072.2019.1587556. Epub 2019 Mar 27. PMID: 30917760.


Here’s How Ketamine actually Works as a Treatment


What People Say

“You have helped me truly discover my happiness, and despite how terrifying this trauma journey can be, I’m getting closer to healing my soul, a spiritual peace, and finally some redemption… and it’s not even about me anymore.” 


Patient , 1/2023

“Thank you so very much Dr. Bautista, for everything you have done for my wife and me! The journey continues to be an amazing and beautiful one. I can honestly say I have never in my life felt the way that I do now. We could not have done this without your help. You are an amazing and gifted person. Please never forget that.”


Patient , 5/2022

“I could not help but reflect on this time, one year ago – when I could not even pick up the phone by myself – and you decided to pull me back out of work for another while. So here I am now, solving problems at work without any angst! Thank YOU! I could never have done this without you.”  


Patient , 1/2023

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